Faculty : Departmental- Primary

Konstantinos Chatzistergos, Ph.D.

The goal of my laboratory is to discover novel stem cell-based regenerative medicine therapies for the treatment of adult and congenital heart diseases. My research is based on developmental biology guided approaches to understand the molecular and cellular mechanisms of cardiac myogenesis and their potential role in adult heart disease and regeneration. More specifically, we focus on the roles of canonical BMP and Wnt signaling pathways on mesoderm and neuroectoderm-derived cardiac precursor cells, and their derivatives in the embryonic and postnatal heart. Our experimental approaches primarily include mouse genetics and human pluripotent stem cell models of neural crest and myocardial lineage development. We are also interested in, and have extensive experience with, translational studies in large and small-animal models of cardiac cell therapy.

View published research articles by Dr. Chatzistergos in the National Library of Medicine