Faculty : Departmental- Primary

Gregory E. Conner, Ph.D.

The airway epithelium represents one of the most important interfaces between an animal and its environment. Approximately 15,000-20,000 liters of air pass through the airways daily during normal breathing, thus exposing the lungs to bacteria, viruses, spores and other particulates. This epithelium provides a sophisticated host defense against airborne material. Our program in airway cell biology studies the function of the epithelial cells and the components of airway secretions that function in respiratory host defense and when dysfunctional may play a role in respiratory diseases.

The role of reactive oxygen species is a focus of the lab. In particular, we study the role of peroxidase and NADPH oxidases in airway host defense and cell signaling with an emphasis on the mechanism and regulation of hydrogen peroxide production by Duox1 and Duox2.

Biographical Information

BA Molecular Biology 1972 Vanderbilt University Nashville, TN.

Ph.D. Biochemistry 1978 University of Florida Gainesville, FL.

Post-Doctoral Cell Biology 1978-1981 The Rockefeller University New York, NY.

Select Publications

View published research articles by Dr. Conner in the National Library of Medicine.

Gattas MV, Jaffe A, Barahona J, Conner GE. Proton channel blockers inhibit Duox activity independent of Hv1 effects. Redox biology. 2020;28:101346.PubMed PMID: 31678720.

Burgueno JF, Fritsch J, Santander AM, Brito N, Fernandez I, Pignac-Kobinger J, Conner GE, Abreu MT. Intestinal Epithelial Cells Respond to Chronic Inflammation and Dysbiosis by Synthesizing H2O2. Frontiers in physiology. 2019;10:1484.PubMed PMID: 31871440.

Ivonnet P, Unwalla H, Salathe M, Conner GE. Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function. Respir Res. 2016;17:15.PubMed PMID: 26857816.

Ivonnet P, Salathe M, Conner GE. Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. Br J Pharmacol. 2015;172(1):173-84.PubMed PMID: 25220136.

Conner GE, Ivonnet P, Gelin M, Whitney P, Salathe M. H2O2 stimulates cystic fibrosis transmembrane conductance regulator through an autocrine prostaglandin pathway, using multidrug-resistant protein-4. Am J Respir Cell Mol Biol. 2013;49(4):672-9.PubMed PMID: 23742099.

Conner GE, Ivonnet P, Salathe M. Hydrogen Peroxide Activates Prostanoid Receptors To Increase Anion Secretion By Human Bronchial Epithelial Cells. Am J Respir Crit Care Med. 2011;279:A4227.

Gattas MV, Forteza R, Fragoso MA, Fregien N, Salas P, Salathe M, Conner GE. Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli. Free Radic Biol Med. 2009;47(10):1450-8.PubMed PMID: 19703552.

Conner GE, Wijkstrom-Frei C, Randell SH, Fernandez VE, Salathe M. The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett. 2007;581(2):271-8.PubMed PMID: 17204267.

Forteza R, Salathe M, Miot F, Forteza R, Conner GE. Regulated hydrogen peroxide production by Duox in human airway epithelial cells. Am J Respir Cell Mol Biol. 2005;32(5):462-9.PubMed PMID: 15677770.

View published research articles by Dr. Conner in the National Library of Medicine.